Department:  Bioquímica y Biología Molecular

Research Unit: Instituto de Neurociencias

Research Gate:

https://www.researchgate.net/scientific-contributions/Alejandro-Berna-Erro-57995755

Research Fields:

-Calcium, SOCE, hemostasis, cancer, neurosecretion

Representative Publications:

• Berna-Erro A, Camello PJ, Granados MP, Delgado E, Fernández E, Teruel-Montoya R, Ferrer-Marín F, Rosado JA, Redondo PC. “STIMATE-mustn1 fusion protein prevents Ca2+ overload in cells that present increased SOCE”. FASEB J. 2026, 40(4): e71507- 71525. DOI: 10.1096/fj.202501504R.
• Redondo PC, Granados MP, Fernández E, Collado-Pérez MA, Teruel-Montoya R, Ferrer-Marín F, Berna-Erro A. “EFCAB13 is a novel age-dependent regulator of SOCE in blood platelets and megakaryoblastic MEG-01 cells”. Thromb Haemost. 2025: Online ahead of print. DOI: 10.1055/a-2689-7785.
• Berna-Erro A#, Lopez JJ, Jardin I, Sanchez-Collado J, Salido GM, Rosado JA# (# Corresponding authors). “Differential functional role of Orai1 variants in constitutive Ca2+ entry and calcification in luminal breast cancer cells”. J Biol Chem. 2024, 300(10): 107786- 107800. DOI: 10.1016/j.jbc.2024.107786.
• Berna-Erro A, Granados MP, Teruel-Montoya R, Ferrer-Marin F, Delgado E, Corbacho AJ, Fenández E, Vazquez-Godoy MT, Tapia JA, Redondo PC. “SARAF overexpression impairs thrombin-evoked Ca2+ homeostasis in neonatal platelets”. Br J Haematol. 2023, 204(3): 988- 1004. DOI: 10.1111/bjh.19210.
• Berna-Erro A#, Ramesh G, Delgado E, Corbacho AJ, Ferrer-Marín F, Teruel R, Granados MP, Rosado JA, Redondo PC# (# Corresponding authors). “CAPN1 (Calpain1)-Dependent Cleavage of STIM1 (Stromal Interaction Molecule 1) Results in an Enhanced SOCE (Store-Operated Calcium Entry) in Human Neonatal Platelets”. Arterioscler Thromb Vasc Biol. 2023, 43(5): 151- 170. DOI: 10.1161/ATVBAHA.122.318015.
• Albarran L, Lopez JJ, Jardin I, Sanchez-Collado J, Berna-Erro A, Smani T, Camello PJ, Salido GM, Rosado JA. “EFHB is a novel cytosolic Ca2+ sensor that modulates STIM1-SARAF interaction”. Cell Physiol Biochem. 2018, 51(3): 1164- 1178. DOI: 10.1159/000495494.
• Berna-Erro A, Izquierdo-Serra M, Sepúlveda RV, Rubio-Moscardo F, Doñate-Macián P, Serra SA, Carrillo-Garcia J, Perálvarez-Marín A, González-Nilo F, Fernández-Fernández JM, Valverde MA. “Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel”. Sci Rep. 2017, 7(1): 10522- 10532. DOI: 10.1038/s41598-017-11274-1.
• López E, Berna-Erro A, López JJ, Granados MP, Bermejo N, Brull JM, Salido GM, Rosado JA, Redondo PC. “Role of mTOR1 and mTOR2 complexes in MEG-01 physiology”. Thromb Haemost. 2015, 114(5): 969- 981. DOI: 10.1160/TH14-09-0727.
• Garcia-Elias A*, Berna-Erro A*, Rubio-Moscardo F, Pardo-Pastor C, Mrkonjić S, Sepúlveda RV, González-Nilo F, Vicente R, Valverde MA# (*first two authors contributed equally). “Interaction between the linker, pre-S1 and TRP domains determines folding, assembly and trafficking of TRPV channels”. Structure. 2015, 23(8): 1404- 1413. DOI: 10.1016/j.str.2015.05.018.
• Albarran L*, Berna-Erro A*#, Dionisio N, Redondo PC, Lopez E, Lopez JJ, Salido GM, Brull Sabate JM, Rosado JA# (*first two authors contributed equally, #Corresponding). “TRPC6 participates in the regulation of cytosolic basal calcium concentration in murine resting platelets”. Biochim Biophys Acta. 2014, 1843(4): 789- 796. DOI: 10.1016/j.bbamcr.2014.01.014.
• Berna-Erro A, Albarran L, Dionisio N, Redondo PC, Alonso N, Gomez LJ, Salido GM, Rosado JA. “The canonical transient receptor potential 6 (TRPC6) channel is sensitive to extracellular pH in mouse platelets”. Blood Cells Mol Dis. 2014, 52(0): 108- 115. DOI: 10.1016/j.bcmd.2013.08.007.
• López E, Berna-Erro A, Bermejo N, Brull JM, Martinez R, Garcia Pino G, Alvarado R, Salido GM, Rosado JA, Cubero JJ, Redondo PC. “Long-term mTOR inhibitors administration evokes altered calcium homeostasis and platelet dysfunction in kidney transplant patients”. J Cell Mol Med. 2013, 17(5): 636- 647. DOI: 10.1111/jcmm.12044.
• López E, Berna-Erro A, Hernández-Cruz JM, Salido GM, Redondo PC, Rosado JA. “Immunophilins are Involved in the Altered Platelet Aggregation Observed in Patients with Type 2 Diabetes Mellitus”. Curr Med Chem. 2013, 20(14): 1912- 1921. DOI: 10.2174/0929867311320140008.
• López E, Berna-Erro A, Salido GM, Rosado JA, Redondo PC. “FKBP52 is involved in the regulation of SOCE channels in the human platelets and MEG 01 cells”. Biochim Biophys Acta. 2013, 1833(3): 652- 662. DOI: 10.1016/j.bbamcr.2012.11.029.
• Berna-Erro A, Galan C, Dionisio N, Gomez LJ, Salido GM, Rosado JA. “Capacitative and non-capacitative signaling complexes in human platelets”. Biochim Biophys Acta. 2012, 1823(8): 1242- 1251. DOI: 10.1016/j.bbamcr.2012.05.023.
• Berna-Erro A, Braun A, Kraft R, Kleinschnitz Ch, Schuhmann MK, Stegner D, Wultsch T, Eilers J, Meuth SG, Stoll G, Nieswandt B. “STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death”. Sci Signal. 2009, 2(93): 67- 77. DOI: 10.1126/scisignal.2000522.