Department: Biochemistry and Molecular Biology

Research Unit: Instituto de Biotecnología y Salud

Research Gate: 

https://www.researchgate.net/profile/Luis-Valor?ev=prf_overview

Research Fields:

-Glioblastoma, Huntington’s disease, transcriptomics, epigenomics

Representative Publications:

• García-Heredia A, Guerra-Núñez L, Iriarte-Gahete M, Espinosa-Lara P, Valor LM*. Tumour immune infiltration is independent of peripheral circulation of white blood cells in glioblastoma. Sci Rep. 2025 Aug 26;15(1):31344. doi: 10.1038/s41598-025-16260-6. PMID: 40858716; PMCID: PMC12381165.
• García-Heredia A, Guerra-Núñez L, Martín-Climent P, Rojas E, López-Domínguez R, Alcántara-Domínguez C, Alenda C, Valor LM*. Transcriptomics and epigenomics datasets of primary brain cancers in formalin-fixed paraffin embedded format. Sci Data. 2025 Feb 15;12(1):273. doi: 10.1038/s41597-025-04597-6. PMID: 39955294; PMCID: PMC11830079.
• Cano-Cano F, Martín-Loro F, Gallardo-Orihuela A, González-Montelongo MDC, Ortuño-Miquel S, Hervás-Corpión I, de la Villa P, Ramón-Marco L, Navarro-Calvo J, Gómez-Jaramillo L, Arroba AI*, Valor LM*. Retinal dysfunction in Huntington’s disease mouse models concurs with local gliosis and microglia activation. Sci Rep. 2024 Feb 20;14(1):4176. doi: 10.1038/s41598-024-54347-8. PMID: 38378796; PMCID: PMC10879138.
• Hervás-Corpión I, Navarro-Calvo J, Martín-Climent P, Iriarte-Gahete M, Geribaldi-Doldán N, Castro C, Valor LM*. Defining a Correlative Transcriptional Signature Associated with Bulk Histone H3 Acetylation Levels in Adult Glioblastomas. Cells. 2023 Jan 19;12(3):374. doi: 10.3390/cells12030374. PMID: 36766715; PMCID: PMC9913072.
• Hervás-Corpión I, Gallardo-Orihuela A, Catalina-Fernández I, Iglesias-Lozano I, Soto-Torres O, Geribaldi-Doldán N, Domínguez-García S, Luna-García N, Romero-García R, Mora-López F, Iriarte-Gahete M, Morales JC, Campos-Caro A, Castro C, Gil-Salú JL, Valor LM*. Potential Diagnostic Value of the Differential Expression of Histone H3 Variants between Low- and High-Grade Gliomas. Cancers (Basel). 2021 Oct 20;13(21):5261. doi: 10.3390/cancers13215261. PMID: 34771425; PMCID: PMC8582563.
• Oegema R, Barakat TS, Wilke M, Stouffs K, Amrom D, Aronica E, Bahi-Buisson N, Conti V, Fry AE, Geis T, Andres DG, Parrini E, Pogledic I, Said E, Soler D, Valor LM, Zaki MS, Mirzaa G, Dobyns WB, Reiner O, Guerrini R, Pilz DT, Hehr U, Leventer RJ, Jansen AC, Mancini GMS, Di Donato N. International consensus recommendations on the diagnostic work-up for malformations of cortical development. Nat Rev Neurol. 2020 Nov;16(11):618-635. doi: 10.1038/s41582-020-0395-6. Epub 2020 Sep 7. PMID: 32895508; PMCID: PMC7790753.
• Gallardo-Orihuela A, Hervás-Corpión I, Hierro-Bujalance C, Sanchez-Sotano D, Jiménez-Gómez G, Mora-López F, Campos-Caro A, Garcia-Alloza M, Valor LM. Transcriptional correlates of the pathological phenotype in a Huntington’s disease mouse model. Sci Rep. 2019 Dec 10;9(1):18696. doi:10.1038/s41598-019-55177-9. PMID: 31822756; PMCID: PMC6904489.
• Hervás-Corpión I, Guiretti D, Alcaraz-Iborra M, Olivares R, Campos-Caro A, Barco Á, Valor LM*. Early alteration of epigenetic-related transcription in Huntington’s disease mouse models. Sci Rep. 2018 Jul 2;8(1):9925. doi: 10.1038/s41598-018-28185-4. PMID: 29967375; PMCID: PMC6028428.