Department: Biochemistry and Molecular Biology

Research Unit: Instituto de Biotecnología y Salud

Research gate: 

http://www.umh.es/contenido/Estudiantes/:persona_3806/datos_es.html

https://www.researchgate.net/profile/Vicente-Micol?ev=hdr_xprf

Research Fields:

-Plant polyphenols and their role in preventing and treating chronic diseases.

-Translational research from molecular mechanisms to human clinical trials.

-Technology transfer and industrial collaboration in food, nutraceuticals, and dermocosmetics.

Representative Publications:

• Pons-Rocamora N, Barrajón-Catalán E, Herranz-López M, Micol V, Álvarez-Martínez FJ. Dermocosmetic Potential of Punica granatum: A Systematic Review of Bioactive Compounds and Skincare Applications. Antioxidants (Basel) 15(3):332 (2026).
• Pomares-Bri I, Roca M, Borrás F, Wabitsch M, Lahoz A, Micol V, Herranz-López M. Polyphenols reverse hyperglycemia-induced adipocyte dysfunction: A Metabolomic and Lipidomic study of efficacy. Food Res Int. 211:116453 (2025).
• Boix-Castejón M, Roche E, Olivares-Vicente M, Álvarez-Martínez FJ, Herranz-López M, Micol V. Plant compounds for obesity treatment through neuroendocrine regulation of hunger: A systematic review. Phytomedicine. 113:154735 (2023).
• Álvarez-Martínez, F.J., Barrajón-Catalán, E., Herranz-López, M., Micol, V. Antibacterial plant compounds, extracts and essential oils: An updated review on their effects and putative mechanisms of action. Phytomedicine 90, 153626 (2021).
• Francisco J Álvarez-Martínez, Enrique Barrajón-Catalán, José Antonio Encinar, Juan Carlos Rodríguez-Díaz, Vicente Micol. Antimicrobial capacity of plant polyphenols against gram-positive bacteria: A comprehensive review. Current Medicinal Chemistry 27 (15), 2576-2606 (2020).
• Ruiz-Torres V, Forsythe N, Pérez-Sánchez A, Van Schaeybroeck S, Barrajón-Catalán E, Micol V. A Nudibranch Marine Extract Selectively Chemosensitizes Colorectal Cancer Cells by Inducing ROS-Mediated Endoplasmic Reticulum Stress. Front Pharmacol. 12:625946 (2021).
• Álvarez-Martínez, F.J., Barrajón-Catalán, E., Micol, V. Tackling antibiotic resistance with compounds of natural origin: A comprehensive review. Biomedicines, 8 (10): 405 (2020).
• Herranz-López, M., Olivares-Vicente, M., Rodríguez-Gallego, E., Encinar, J.A., Pérez-Sánchez, A., Ruiz-Torres, V., Joven, J., Roche, E. & Micol, V. Quercetin metabolites from Hibiscus sabdariffa contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro. Food and Chemical Toxicology, 144, 111606 (2020).
• Boix-Castejón, M., Herranz-López, M., Pérez-Gago, A., Olivares-Vicente, M., Caturla, N., Roche, E., Micol, V. Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial. Food Func. 9(6):3173-3184 (2018).

Patents:

1. Patent: “Equipo de expansión a vacío y ultrasonidos”. Reference: 201200830 Filing date: 09/08/2012; Priority date (granted): 13/06/2014 International Patent Classification: PCT/ES2013/000191. Filing Date: 08/08/2013. European Priority Reference: 13827136.6

   Under exploitation through know-how transfer license agreement with reference: MITRASOLTEC3.16LP. N. of inventors: 6.

   Exploitation period: 13/05/2016 – 12/05/2032.  Company: MITRA SOL TECHNOLOGIES SL

2. Patent: “Combinación sinérgica de polifenoles con actividad antibiótica eficaz frente a cepas de bacterias resistentes a antibióticos”. Reference: 201301181

   Filing date: 11/12/2013                      Priority date (granted): 29/04/2016

   Under exploitation through know-how transfer license agreement with reference: MITRASOLTEC1.16LP. N. of inventors: 7. Exploitation initial date: 13/05/2016 – Exploitation final date: 12/05/2033. Company: MITRA SOL TECHNOLOGIES SL

3. Patent: “Método de producción de pectina modificada de cítricos”. Reference: 201301183.

   Filing date: 11/12/2013          Priority date (granted): 21/04/2016

   Under exploitation through know-how license agreement with reference: MITRASOLTEC2.16LP  N. of inventors: 6. Company: MITRA SOL TECHNOLOGIES SL

   Exploitation initial date: 13/05/2016;            Exploitation final date: 12/05/2033

4. Patent: “Combinación sinérgica de flavonoides y Vitamina C”. Reference: 201300578

   Filing date: 05/06/2013;         Priority date (granted):13/06/2014

   Under exploitation through know-how transfer license agreement with reference: MITRASOLTEC4.16LP. N. of inventors: 6.           Company: MITRA SOL TECHNOLOGIES SL

   Exploitation initial date: 13/05/2016;            Exploitation final date: 12/05/2033

5. Patent: “Extracción de compuestos biológicamente activos a partir de residuos de la industria de la vinificación”. Reference: 201500423.

   Filing date: 05/06/2015;         Priority date (granted): 21/09/2017

   Under exploitation through know-how transfer license agreement with reference: MITRASOLTEC2.15LP. N. of inventors: 7. Company: MITRA SOL TECHNOLOGIES SL

   Exploitation initial date: 29/07/2015;            Exploitation final date: 05/06/2035

6. Patent: “Composición para el control del peso a través de la modulación de los niveles de péptidos involucrados en saciedad y/o apetito” Reference: 20170294/2026; P201731147

   Company: Monteloeder/UMH. N. of inventors: 5.

   Filing Date: 25/09/2017;        Priority date (granted): 25/10/18

   US and International Patent Classification: US 2020/0268823 (PCT/ES2018/070600).

Company agreements:

• Nutrafur SA.
• Innovation Labo, SL.