Research Unit: Instituto de Neurociencias

Web page: 

https://www.umh.es/contenido/Universidad/:persona_4049/datos_es.html

http://in.umh-csic.es/personal-detalle.aspx?personal=47

Research Fields: Altered molecular mechanism in Alzheimer’s disease and dementia
1. The role of acetylcholinesterase in the pathogenesis, therapy and diagnostic of Alzheimer´s disease.
2. Diagnostic markers for Alzheimer.
3. Reelin in neurodegenerative disorders.
4. Altered expression of cholinesterases in cirrhosis and hepatic encephalopathy.

Representative Publications

• Silveyra MX. , Evin, G; Montenegro, MF; Vidal, CJ; Martínez, S; Culvenor, J; Sáez-Valero, J. (2008). Presenilin-1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation.  Mol Cell Biol.  28: 2908 – 2919 .
• Garcia-Ayllon MS. , Silveyra MX.,Andreasen N.,Brimijoin S.,Blennow K.,Saez-Valero J. (2007) Cerebrospinal fluid acetylcholinesterase changes after treatment with donepezil in patients with Alzheimer’s disease. J Neurochem. 101: 1701 – 1711 .
• Garcia-Ayllon MS. , Silveyra MX.,Candela A.,Compañ A.,Claria J.,Jover R.,Perez-Mateo M.,Felipo V.,Martinez S.,Galceran J., Saez-Valero J. (2006). Changes in liver and plasma acetylcholinesterase of rats with bile duct ligation. « Hepatology . 43 : 444 – 453 .
• Botella-Lopez A., Burgaya, F; Gavin, R; Garcia-Ayllon, MS; Gomez-Tortosa, E; Peña-Casanova, J; Ureña, JM; Del Rio, JA; Blesa, R; Soriano, E; Saez-Valero, J. (2006). Reelin expression and glycosylation patterns are altered in Alzheimer’s disease. Proc Natl Acad Sci USA. 103: 5573 – 5578.
• Sáez-Valero J. , Sberna G., McLean C.A., Masters C.L., Small D.H. (1997). Glycosylation of acetylcholinesterase as diagnostic marker for Alzheimer’s disease. The Lancet . 350: 929 – 929 .