Department: Bioquímica y Biología Molecular

Research Unit: Instituto de Biotecnología y Salud

Web page: 

http://www.umh.es/contenido/Estudiantes/:persona_28249/datos_es.html

Research Fields:
-Study of the molecular mechnisms involved in chemorresistance acquisition in cancer.

-Search of new therapeutical targets for the treatment of chemorresistant tumors.

-Regulation of expression and activity of ABC proteins.

Representative Publications:

• Castro-Galache M.D., Ferragut, J.A., Barberá V.M., García-Morales, P., González-Ros, J.M., Saceda, M. (2003). Apoptosis induction and down-regulation of P-glycoprotein by Trichostatin A in a Daunorubicin-Resistant murine leukemia cell line. Int. J. Cancer 104:579-586.
• García-Morales, P., Gomez-Martinez, A., Carrato, A., Martinez-Lacaci, M.I., Barbera, V.M., Soto, J.L., Carrasco-García, E., Menéndez-Gutierrez, M.P., Castro-Galache, M.D., Ferragut, J.A., Saceda, M. (2005). Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines. Mol Cancer Ther. 4(8): 1222-1230.
• García-Morales, P., Hernando, E., Carrasco-Garcia, E., Menéndez-Gutierrez, M.P., Saceda, M., Martinez-Lacaci, I. (2006). Cyclin D3 is down regulated by rapamycin in HER2-overexpresing breast cancer cells. Mol. Cancer Therap. 5 (9): 2172-2181.
• García-Morales P., Carrasco-García E., Ruiz-Rico P., Martínez-Mira R., Menéndez-Gutiérrez MP., Ferragut JA., Saceda M., Martínez-Lacaci I. (2007). Inhibition of Hsp90 function by ansamycin causes downregualtion of cdc2 and cdc25c and G(2)M arrest in glioblastoma cell lines. Oncogene 26(51): 7185-7193.
• Gomez-Martinez, A., García-Morales, P., García-Poveda, E., Carrato, A., Castro-Galache, M.D., Soto, J.L., Ferragut, J.A., Saceda, M. (2007). Post-transcriptional regulation of P-glycoprotein expresión in colon carcinoma cell lines.  Mol. Cancer Res. 5(6): 641-653.