Department: Biochemistry and Molecular Biology

Research Unit: Instituto de Neurociencias

Research Gate:

https://www.researchgate.net/profile/Jose-Villanueva-4

Research Fields:

-Biochemistry

-Neurosecretion

 Representative Publications:

• Scientific article. Aznar-Escolano, B., Royo, M., Madrigal, M.P., Portales Montes, A.; Villanueva J. et al.SNAP-47 mediates somatic oxytocin dynamics in hypothalamic neurons. Commun Biol 9, 137 (2026). https://doi.org/10.1038/s42003-025-09442-5
• Scientific article. Gil, ; González-Vélez, V.; Gutiérrez, L.M.; Villanueva, J.2024. The role of nicotinic receptors on Ca2+ signaling in bovine chromaffin cells. Current Issues in Molecular Biology. MDPI. 46, pp.808-820. ISSN 1467-3045.
• Scientific article. José Villanueva; Manuel Criado; Yolanda Giménez Molina; Virginia González Vélez; Amparo Gil; Luis Miguel Gutiérrez. α3β4 Acetylcholine Nicotinic Receptors Are Components of the Secretory Machinery Clusters in Chromaffin Cells.International Journal of Molecular Sciences.MDPI Open Access Journals. 23 (16)-9101, pp.2-13.
• Scientific article. Johanna Guadalupe Peña del Castillo; Pedro Segura‑Chama; Ruth Rincón‑Heredia; Diana Millán‑Aldaco; Yolanda Giménez‑Molina; José Villanueva; Luis Miguel Gutiérrez; Arturo Hernández‑ 2021. Development of the hypersecretory phenotype in the population of adrenal chromaffin cells from prehypertensive SHRs.flügers Archiv-European Journal of Physiology.Springer. 473-11, pp.1775-1793.
• Scientific article. YolandaGimenez-Molina; VirginiaGarcía-Martínez; José Villanueva; Bazbek Davletov; Luis Miguel Gutiérrez. Multiple sclerosis drug FTY-720 toxicity is mediated by the heterotypic fusion of organelles in neuroendocrine cells.Scientific Reports. Nature. 9-18471, pp.1-13.
• Scientific article. Yolanda Gimenez-Molina; José Villanueva; María del Mar Francés; Salvador Viniegra; Luis Miguel Gutiérrez. Multiple mechanisms driving F-actin-dependent transport of organelles to and from secretory sites in bovine chromaffin cells.Frontiers in cellular neuroscience.Frontiers. 12-344, pp.1-13.
• Scientific article. Gerardo J. Félix-Martínez; Amparo Gil; Javier Segura; José Villanueva; Luis Miguel Gutiérrez. Modeling the influence of co-localized intracellular calcium stores on the secretory response of bovine chromaffin cells.Computers in Biology and Medicine.Elsevier. 100, pp.165-175.
• Scientific article. Frederic Darios; Jernej Jorgacevsk; Ajda Flašker; et al; Bazbek Davletov. 2017. Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion. Scientific reports. Nature. 7-5958, pp.1-11.
• Scientific article. José Villanueva; Yolanda Giménez Molina; Salvador Viniegra; Luis Miguel Gutiérrez. F-actin cytoskeleton and the fate of organelles in chromaffin cells.Journal of Neurochemistry. Wyley online library. 137-6, pp.860-866.
• Scientific article. Virgínia García Martínez; Mari Angeles Montes; José Villanueva; Yolanda Giménez Molina; Guillermo Alvarez de Toledo; Luis MIguel Gutiérrez. Sphingomyelin derivatives increase the frequency of microvesicle and granule fusion in chromaffin cells. Neuroscience. Elsevier. 295, pp.117-125.
• Scientific article. José Villanueva; Salvador Viniegra; Yolanda Giménez Molina; Virginia García Martínez; Giovanna Expósito Romero; María del Mar Francés; Javier García Sancho; Luis Miguel Giutiérrez. The position of mitochondria and ER in relation to that of the secretory sites in chromaffin cells. Journal of Cell Science. 127-23, pp.5105-5114.
• Scientific article. Virginia García Martínez; José Villanueva; Cristina Juana Torregrosa Hetland; Robert Bittman; Ashlee Higdon; Victor Darley Usmar; Bazbek Davletov; Luis Miguel Gutiérrez. 2013. Lipid Metabolites Enhance Secretion Acting on SNARE Microdomains and Altering the Extent and Kinetics of Single Release Events in Bovine Adrenal Chromaffin Cells. Plos One. 8-9, pp.1-13.
• Scientific article. Torregrosa Hetland; José Villanueva; Virginia Garcia Martínez; Giovanna Expósito Romero; María del Mar Francés; Luis Miguel Gutiérrez Pérez. 2013. Cortical F-actin affects the localization and dynamics of SNAP-25 membrane clusters in chromaffin cells. The International Journal of Biochemistry & Cell Biology. Elsevier. 45, pp.583-592.
• Scientific article. José Villaneva; Vanesa Torres; Cristina Juana Torregrosa Hetland; Virginia García Martínez; Inmaculada López Font; Salvador Viniegra; Luis Miguel Gutiérrez. F-Actin-Myosin II Inhibitors Affect Chromaffin Granule Plasma Membrane Distance and Fusion Kinetics by Retraction of the Cytoskeletal Cortex. Journal of Molecular Neuroscience. Springer Link. 48, pp.328-338.
• Scientific article. Fréderic Darios; Violeta Ruiperez; Inmaculada López; José Villanueva; Luis Miguel Gutiérrez; Bazbek Davletov. α-Synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis. EMBO reports. EMBO press. 11-7, pp.528-533.
• Scientific article. Inmaculada López; José Antonio Ortiz; José Villanueva; Vanesa Torres; Cristina Juana Torregrosa Hetland; Maria del Mar Francés; Salvador Viniegra; Luis Miguel Gutiérrez. Vesicle Motion and Fusion are Altered in Chromaffin Cells with Increased SNARE Cluster Dynamics. Traffic. Wiley online library. 10-2, pp.172-185.
• Scientific article. Daniel Giner; Inmaculada López; José Villanueva; Vanesa Torres; Salvador Viniegra; Luis Miguel Gutiérrez. Vesicle movements are governed by the size and dynamics of F-actin cytoskeletal structures in bovine chromaffin cells. Neuroscience. Elsevier. 146-2, pp.659-669.
• Literature review. José Villanueva; Yolanda Giménez Molina; Bazbek Davletov; Luis Miguel Gutiérrez. Vesicle Fusion as a Target Process for the Action of Sphingosine and Its Derived Drugs.International Journal of Molecular Sciences.MDPI Open Access Journals. 23 (3)-1086, pp.1-13.
• Literature review. Virginia Gracía Martínez; Yolanda Giménez Molina; José Villanueva; Frederic D. Darios; Bazbek Davletov. Emerging evidence for the modulation of exocytosis by signalling lipids.Febs Letters.FEBS press. 592 Open access, pp.3493-3503.
• Literature review. Yolanda Giménez-Molina; Jose Villanueva; Carmen Nanclares; et al; Luis Miguel Gutiérrez. The differential organization of F-actin alters the distribution of organelles in cultured when compared to native chromaffin cells. Frontiers in cellular neuroscience. 11-135, pp.1-12.