Research Unit: Instituto de Biología Molecular y Celular

Web page: 

https://www.umh.es/contenido/Universidad/:persona_4172/datos_es.html

https://ibmc.umh.es/gonzalez-ros-jm.asp

Research Fields:
Structure/Function relationships in membrane proteins: Neuroreceptors and ion channels. Lipid-Protein and Protein-Protein interactions in biological membranes. Potential applications to drug discovery.

Representative Publications:

• A. M. Fernández, J. A. Poveda, J. A. Encinar, A. Morales and J. M. Gonzalez-Ros (2006) Estructural and functional modulation of ion channels by specific lipids: from model systems to cell membranes, in Protein-Lipid interactions: New approaches and emerging concepts (C. R. Mateo, J. Gómez, J.Villalaín and J. M. González Ros, Eds.), pp. 203-231, Springer Series in Biophysics 9. Springer, Heidelberg.
• M. L. Molina, F. N. Barrera, A. M. Fernandez, M. L.Renart, J. A. Poveda, J. A. Encinar, G. Riquelme and J. M. Gonzalez-Ros. (2006). Clustering and coupled gating modulate the activity in KcsA, a potassium channel model. J. Biol. Chem. 281, 18837-18848.
• M. L. Renart, F. N. Barrera, M. L. Molina, J.A. Encinar, J. A. Poveda, A. M. Fernández, G. Riquelme, J. Gómez and J. M. Gonzalez-Ros (2006). Effects of conducting and blocking ions on the structure and stability of the potassium channel KcsA”. J. Biol. Chem. 281, 29905-29915
• F. Barrera, M.L. Renart, J.A. Poveda, B. de Kruijff, A.J. Killian and J.M. Gonzalez-Ros (2008). Protein self-assembly and lipid binding in the folding of the potassium channel KcsA. Biochemistry 47, 3123-2133.
• I. Triano, F.N. Barrera, M.L. Renart, M.L. Molina, G. Fernandez-Ballester, J.A. Poveda, A.M. Fernandez, J.A. Encinar, A.V. Ferrer-Montiel, D. Otzen and J.M. Gonzalez-Ros (2010). Occupancy of non-annular lipid binding sites on KcsA greatly increases the stability of the tetrameric protein. Biochemistry, 49(25): 5397-5404.

Patents and Available Technologies:

A DEVICE FOR ADMINISTRATION OF MEDICATION BY IONTOPHORESIS FOR LOCAL-REGIONAL TREATMENT. Patente Europea número 90100236.0, Año 1995.