Department: Biochemistry and Molecular Biology

Research Unit: Instituto de Biotecnología y Salud (IDiBE)

Web page: 

https://www.umh.es/contenido/Universidad/:persona_3718/datos_es.html

http://adan-embl.ibmc.umh.es/gregorio/

Research Fields:
-Computational protein design and engineering. Protein-protein and protein-drug interactions. Molecular modeling of soluble and membrane proteins. Protein domains and ligand specificity.

Representative Publications:

• C. Martín-Escura; A. Medina-Peris; L.A. Spear; R. de la Torre Martínez; L.A. Olivos-Oré; M.V. Barahona; S. González-Rodríguez; G. Fernández-Ballester; A. Fernández-Carvajal; A.R. Artalejo; A. Ferrer-Montiel; R. González-Muñiz. β-Lactam TRPM8 antagonist RGM8-51 displays analgesic activity in different animal models. International Journal of Molecular Sciences. 23, 2692 (2022).  Doi: https://doi.org/10.3390/ijms23052692. I= 6.208. IC= Q1.
• S. Gonzalez-Foutel; J. Glavina; W.M. Borcherds; M. Safranchik; S. Barrera-Vilarmau; A. Sagar; A. Estana; A. Barozet; N.A. Garrone; G. Fernandez-Ballester; C. Blanes-Mira; I.E. Sanchez; G. de Prat-Gay; J. Cortes; P. Bernado; R.V. Pappu; A.S. Holehouse; G.W. Daughdrill; L.B. Chemes. Conformational buffering underlies functional selection in intrinsically disordered protein regions. Nat Struct Mol Biol. 29, 781-790 (2022). Doi: https://doi.org/10.1038/s41594-022-00811-w. I= 18.36. IC= Q1.
• A. Fernández-Carvajal; G. Fernández-Ballester; A. Ferrer-Montiel. TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy. Front. Mol. Neurosci. 15:930964, pg: 1-14 (2022).  Doi: https://doi.org/10.3389/fnmol.2022.930964. I= 6.261. IC= Q1.
• D. Alarcón-Alarcón; D. Cabañero; J. de Andrés-López; M. Nikolaeva-Koleva; S. Giorgi; G. Fernández-Ballester; A. Fernández-Carvajal; A. Ferrer-Montiel. TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine. Nature Communications 13:6304. (2022). Doi: https://doi.org/10.1038/s41467-022-33835-3. I= 17.69. IC= Q1.
• D. Cabañero; E. Villalba-Riquelme; G. Fernández-Ballester; A. Fernandez-Carvajal; A. Ferrer-Montiel. ThermoTRP Channels in Pain Sexual Dimorphism: New Insights for Drug Intervention. Pharmacology & Therapeutics, Volume 240, 108297. (2022) doi: https://doi.org/10.1016/j.pharmthera.2022.108297. I= 13.4. IC= Q1.
• C. Blanes-Mira, P. Fernández-Aguado, J. de Andrés-López, A. Fernández-Carvajal, A. Ferrer-Montiel; G. Fernández-Ballester. Comprehensive survey of consensus docking for high-throughput virtual screening. Molecules. 28, 175 (2023). doi: https://doi.org/10.3390/molecules28010175. I= 4.927. IC= Q2.
• G. Fernández-Ballester; A. Fernández-Carvajal; A. Ferrer-Montiel.Progress in the structural basis of thermoTRP channel polymodal gating.International Journal of Molecular Sciences. 24(1), 743. (2023) Doi: https://doi.org/10.3390/ijms24010743. I= 4.9. IC= Q1.
• C. Martín-Escura; M.A. Bonache; J.A. Medina; A. Medina-Peris; J. De Andrés-López; S. González-Rodríguez; S. Kerselaers; G. Fernández-Ballester; T. Voets; A. Ferrer-Montiel; A. Fernández-Carvajal; González-Muñiz R. β-Lactam TRPM8 Antagonists Derived from Phe-Phenylalaninol Conjugates: Structure-Activity Relationships and Antiallodynic Activity. International Journal of Molecular Sciences. 24(19), 14894. (2023) Doi: https://doi.org/10.3390/ijms241914894. I= 4.9. IC= Q1.
• L. Butron; M. Nikolaeva-Koleva; A. Sempere; V. Rivero; G. Fernandez-Ballester; A. Espinosa; M. Vergassola; E. Mastrocola; A. Zucchi; L. Ragni; A. Fernández-Carvajal; G. Mangano; A. Ferrer-Montiel; I. Devesa. Design and validation of neuronal exocytosis blocking peptides as potential novel antiperspirants. Experimental Dermatology, 32(7):999-1006 (2023). doi: https://doi.org/10.1111/exd.14804. I= 3.5. IC= Q1.
• Sastre; M. Colomer-Molera; A. de Benito-Bueno; C. Valenzuela; G. Fernández-Ballester; A. Felipe. KCNE4-dependent modulation of Kv1.3 pharmacology. Biochemical Pharmacology 226, 116368. (2024) . doi https://doi.org/10.1016/j.bcp.2024.116368. IF= 5.3 (2023). Q= Q1. D1= No (89th).
• M. Nikolaeva-Koleva; L. Butron; A. Sempere; V. Rivero; G. Fernández-Ballester; A. Espinosa; M. Vergassola; E. Mastrocola; S. Zucchi; L. Ragni; G. Mangano; I. Devesa. Design and Validation of Novel Potential Antiperspirant Peptides Blocking M3-Gαq Sweat Signaling Cascade. Int J Pept Res Ther 30, 47 (2024). doi: https://doi.org/10.1007/s10989-024-10628-4 IF= 2 (2023). Q= Q2. D1= No (65th).
• A. Lamberti; M. Serafini; S. Aprile; I.P. Bhela; G. Goutsiou; E. Pessolano; G. Fernandez-Ballester; A. Ferrer-Montiel; R.M.C. Di Martino; A. Fernandez-Carvajal; T. Pirali. The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators. Eur J Med Chem. 279:116845 (2024). doi: https://doi.org/10.1016/j.ejmech.2024.116845. I= 6 (2023). Q= Q1. D1= Si (95th).
• A. Luque; C. Blanes-Mira; L. Caballero; P.A. Martínez-Melgarejo; M. Nicolás-Albujer; F. Pérez-Alfocea; G. Fernández-Ballester; J.M. Pérez-Pérez. Identification of novel inhibitors of plant GH3 IAA-amido synthetases through molecular docking studies. Physiologia Plantarum (2024) 176(6):e14612. doi: https://doi.org/10.1111/ppl.14612. IF=5.4 (2023). Q= Q1. D1= Si (90th).
• D. Sastre; M. Colomer-Molera; S. Roig; A. de Benito-Bueno; P. Socuellamos; G. Fernández-Ballester; C. Valenzuela; A. Felipe. Molecular mapping of KCNE4-dependent regulation of Kv1.3. American Journal of Physiology-Cell Physiology. 327(6), C1497-C1513 (2024). doi https://doi.org/10.1152/ajpcell.00499.2024. IF= 5(2023). Q= Q1. D1= No (83rd).
• I. Devesa,G. Fernández-Ballester, A. Fernandez-Carvajal & A. Ferrer-Montiel. A review of the patent literature surrounding TRPV1 modulators. Expert Opin Ther Pat. Feb 20:1-15 (2025). Doi: 10.1080/13543776.2025.2467698.  IF= 4,6 (2024). Q= Q1. D1= No
• A. Lamberti, S. Aprile, D. Cabañero, F. Travagin, L. Butron, G. Fernández-Ballester, G.C. Tron, A. Fernández-Carvajal, A. Ferrer-Montiel & U. Galli. An adamantane-based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation. FEBS J. 292(13):3449-3476 (2025). doi https://doi.org/10.1111/febs.70065. IF= 4,2 (2024). Q= Q1. D1= No.

Patents and Available Technologies:

1. Grande Pérez, Ana; Viguera Mínguez, Enrique; Fernandez Escamilla, Ana María; Fernández Ballester, Gregorio Joaquín; Ortega Del Campo, Sergio; Blanes Mira, María Clara; Viciana Ramos, María Isabel; Clavijo Frutos, Encarnación; Santos González, Jesús Leandro. Título: 5-fluorouracilo como agente antiviral contra virus de la familia Coronaviridae. Nº de registro: P202330781// PCT/ES2024/070571. Date of filing: 20.09.2023. Entidad titular: UMA-UMH.
2. García Sanz, Nuria; Sempere Bonete, Ana; de Andrés López, Jorge; Fernández Ballester, Gregorio; Ferrer Montiel, Antonio Vicente; Devesa Giner, Isabel. Título: Phospholipase C Inhibitor Peptides And Uses Thereof. Nº de registro: WO 2025/132812 // PCT/EP2024/087437. Date of filing: 26.06.2025. Entidad titular: UMH.