Department: Biochemistry and Molecular Biology

Research Unit: Instituto de Neurociencias

Research Gate:

https://www.researchgate.net/profile/Luis-Gutierrez-35

Research Fields:

-Exocytosis, Molecular Mechanisms, SNAREs, Cytoskeleton, FTY-720, neuroscretion, cancer

Representative Publications:

• Gimenez-Molina, Y, Garcia-Martinez,V., Villanueva, J., Davletov, B, and Gutiérrez, L.M. (2019). Multiple sclerosis drug FTY-720 toxicity is mediated by the heterotypic fusion of organelles in neuroendocrine cells. Reports 9: 18471-18482.´
• Garcia-Martinez, V., Gimenez-Molina, Y., Villanueva, J., Darios, F.D., Davletov, B. and Gutiérrez, L.M. (2018). Emerging evidence for the modulation of exocytosis by signalling lipids. FEBBS letters. 592:3493-3503.Invited review.
• Gimenez-Molina Y, Villanueva, Francés, MM, Viniegra, S. and Gutiérrez, LM (2018). Multiple Mechanisns driving the F-actin-dependent transporr of organelles to and from secretory sites in bovine chromaffin cells. Frontiers in Cellular Neuroscience. 12: 344.
• Darios FD, Jorgacevski J, Flašker A, Zorec R, García-Martinez V, Villanueva J, Gutiérrez LM, Leese C, Bal M, Nosyreva E, Kavalali ET, Davletov B.(2017). Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion. Report 7:5958-5971.
• Meunier, FA, Gutiérrez LM. (2016). Captivating new roles of F-actin cortex in exocytosis and bulk endocytosis in neuroendocrine cells. 39, 605-613.Invited review.
• Villanueva J, Viniegra S, Gimenez-Molina Y., García-Martinez V, Exposito-Romero G, Francés Mm, García-Sancho J, Gutiérrez LM. (2014) The position of mitocondria and ER in relation to that of the secretory sites in chromaffin cells. Cell. Science. 127: 5105-5114.
• Garcia-Martinez v, Villanueva J, Torregrosa-Hetland CJ, Bittman R, Higdon A, Darley-Usmar VM, Davletov B, Gutiérrez LM (2013). Lipid Metabolites Enhance secretion actino n SNARE Microdomains ans altering the Extent and Kinetics of Single Release Events in Bovine Adrenal Chromaffin Cells. PLOs One 8: e75845-55.
• Gutiérrez LM. (2012). New insights into the role of the cortical cytoskeleton in exocytosis from neuroendocrine cells. Int Rev Cell Mol Biol. 295:109-37.Invited review.
• Torregrosa-Hetland, C-J., Villanueva, J., Giner, D., Lopez-Font, I., Nadal, A., Quesada, I., Viniegra, S., Exposito-Romero, G., Gil, A., Gonzalez-Velez, V., Segura^,   and Luis M. Gutiérrez (2011). The F-actin cortical network is a major factor influencing the organization of the secretory machinery in chromaffin cells. J. Cell. Sci.  124: 727-734.
• Darios, F., Ruipérez, V., López-Font, I., Villanueva, J., Gutiérrez, L.M., and Davletov, B. (2010). Α-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis. EMBO reports. 11: 528

Patents and Available Technologies: 

Títle:                   Aplicaciones cosméticas y biomédicas de una familia de péptidos inhibidores de la exocitosis neuronal

Authors:            Antonio V. Ferrer Montiel, Rosa Planells Cases, Clara Blanes Mira, Mercedes Llobregat, Gregorio Fernández Ballester, Luis M. Gutiérrez, Anabel Gil, Salvador Viniegra, Teresa Carbonell y Enrique Pérez-Payá.

 Nº PATENT    9900844  (ESPAÑA)

PCT:                 WO 00/64932 (EXTENSION INTERNACIONAL. EEUU Y CEE).

Patent under production by LIPOTEC SA.