Department: Biochemistry and Molecular Biology

Research Unit: Instituto de Biotecnología y Salud (IDiBE)

Research Gate:

https://www.researchgate.net/profile/Isabel-Devesa

Other links

ORCID ID: 0000-0003-0922-453X  https://orcid.org/0000-0003-0922-453X

Scopus Author ID: 56024299700 https://www.scopus.com/authid/detail.uri?authorId=56024299700ç

ResearcherID: A-8244-2019

LinkedIn https://es.linkedin.com/in/isabel-devesa-giner-817b0051

Google Scholar https://scholar.google.com/citations?user=6sLUOj0AAAAJ&hl=es

Research Fields:

-Pain,  ion channels, peripheral neuropathy, inflammation, sensory neuron, pharmacology, drug discovery, drug developmentssistant Professor

Representative Publications:

• A review of the patent literature surrounding TRPV1 modulators. Devesa I, Fernández-Ballester G, Fernandez-Carvajal A, Ferrer-Montiel A. Expert Opin Ther Pat. 2025. 35(5):477-491. https://doi.org/10.1080/13543776.2025.2467698
• Design and validation of neuronal exocytosis blocking peptides as potential novel antiperspirants. Butron L, Nikolaeva-Koleva M, Sempere A, et al., Devesa I . Experimental Dermatology. 2023. 32(7):999-1006. https://doi.org/10.1111/exd.14804
• Benzydamine plays a role in limiting inflammatory pain induced by neuronal sensitization. Nikolaeva-Koleva M, Espinosa Martinez AB, Vergassola M, et al., Devesa I. Molecular pain. 2023.  19, 1-12. https://doi.org/10.1177/17448069231204191
• Design and Validation of Novel Potential Antiperspirant Peptides Blocking M3-Gαq Sweat Signaling Cascade. Nikolaeva Koleva, M, Butron L, Sempere A, et al., Devesa, I. International Journal of Peptide Research and Therapeutic. 2024. 30-47. https://doi.org/10.1007/s10989-024-10628-4
• A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability.Nikolaeva Koleva M, Butron L, Gonzalez Rodriguez S, Devesa I, et al., Ferrer Montiel A. Scientific Reports. 2021. 11-246. https://doi.org/10.1038/s41598-020-80725-z.
• Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target. Butrón D, Zamora Carreras H, Devesa I, et al., Gonzalez Muñiz R. DD04107- Biororganic Chemistry. 2021. 115-105231, pp.1-15. https://doi.org/10.1016/j.bioorg.2021.105231
• A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration. González Gil I, Debora Zian, Vázquez Villa H, Hernández-Torres G, Martínez F, Khiar-Fernández N, Rivera R, G, Devesa I et al, Ortega Gutiérrez S. J Med Chem. 2020. 63-5, pp.2372-2390. https://doi.org/10.1021/acs.jmedchem.9b01287
• Targeting Transient Receptor Potential Vanilloid 1 (TRPV1) Channel Softly: The Discovery of Passerini Adducts as a Topical Treatment for Inflammatory Skin Disorders Serafini M, Griglio A, Aprile S, Seiti F, Travelli C, Pattarino F, Grosa G, Sorba G, Genazzani AA, Gonzalez-Rodriguez S, Butron L, Devesa I, Fernández-Carvajal A, Ferrer-Montiel A. J Med Chem 2018. 61-10, 4436-4455. https://doi.org/10.1021/acs.jmedchem.8b00109
• Bradykinin Induces TRPV1 Exocytotic Recruitment in Peptidergic Nociceptors. Mathivanan S, Devesa I, Changeux PJ, Ferrer Montiel A. Front Pharmacol. 2016Lausanne: Frontiers Medi. 23-7, pp.178. https://doi.org/10.3389/fphar.2016.00178
• aCGRP is essential for algesic exocytotic: Mobilization of TRPV1 channels in peptidergic neurons. Devesa I, Ferrándiz Huertas C; Mathivanan S, Wolf C, Changeux JP, Lujan R, Ferrer Montiel A. PNAS. 2014. 111-51, 18345-18350. https://doi.org/10.1073/pnas.1420252111

Patents and Available Technologies: 

1. Nuria Garcia Sanz; Ana Sempere Bonete; Jorge de Andrés López; Gregorio Fernández Ballester; Antonio Ferrer Montiel; Isabel Devesa Giner. Phospholipase C inhibitor peptides and uses thereof. 20/12/2023. AntalGenics SL.
2. Francesca Mancini; Isabel Devesa Giner; Antonio Ferrer Montiel; Gregorio Fernandez Ballester; Giorgina Mangano; Cristina Bartella. Peptides having inhibitory activity on muscarinic receptor M3. 13/06/2018. Aziende Chimiche Riunite Angelini Francesco ACRAFT SpA.
3. Francesca Mancini; Isabel Devesa Giner; Antonio Ferrer Montiel; Gregorio FernandezBallester; Giorgina Mangano; Cristina Bartella. Peptides having inhibitoryactiviy on neuronal exocytosis. 13/06/2018. Aziende Chimiche Riunite Angelini Francesco ACRAFT SpA.
4. Ariadna Grau Campistany; Silvia Pastor; Patricia Carull; Juan Carlos Escudero; Julia Boras; Antonio Ferrer Montiel; Isabel Devesa Giner; Gregorio Fernandez Ballester. Peptides and compositions for use in cosmetics and medicine. 27/02/2018. Lipotrue SL.
5. Isabel Devesa Giner; Armando Genazzani; Tracey Pirali; Asia Fernandez Carvajal;Antonio Vicente Ferrer Montiel. TRPV1 modulator compounds. 11/05/2017. AntalGenics SL.