Department: Biochemistry and Molecular Biology

Research Unit: Instituto de Biotecnología y Salud (IDiBE)

Web page: 

https://ibmc.umh.es/antiviral-immunology.asp

http://www.umh.es/contenido/pdi/:persona_140830/datos_es.html

Research Fields:

Fish immunology and virology.

Representative Publications:

• Salvador-Mira M, Rojas-Peña M, Chico V, Aceituno P, Roher N, Perez L, ORTEGA-VILLAIZAN M. Erythrocyte-targeted recombinant subunit vaccine: A novel approach to improve viral vaccines in fish. Fish Shellfish Immunol. 2026. DOI: 10.1016/j.fsi.2025.110971
• Salvador-Mira M, Gimenez-Moya P, Manso-Aznar A, Sánchez-Córdoba E, Sevilla-Diez MA, Chico V, Nombela I, Puente-Marin S, Roher N, Perez L, Dučić T, Benseny-Cases N, Perez-Berna AJ, ORTEGAVILLAIZAN M. Viral vaccines promote endoplasmic reticulum stress-induced unfolding protein response in teleost erythrocytes. Eur J Cell Biol. 2025. DOI: 10.1016/j.ejcb.2025.151490.
• Salvador-Mira M, Sanchez-Cordoba E, Solivella M, Nombela I, Puente-Marin S, Chico V, Perez L, PerezBerna AJ, ORTEGA-VILLAIZAN M. Endoplasmic reticulum stress triggers unfolded protein response as an antiviral strategy of teleost erythrocytes. Front Immunol. 2024. DOI: 10.3389/fimmu.2024.1466870.
• Puente-Marin S., Cazorla D., Chico V., Coll J., ORTEGA-VILLAIZAN M. Innate immune response of rainbow trout erythrocytes to spinycterins expressing a downsized viral fragment of viral haemorrhagic septicaemia virus. Aquaculture 2023. DOI: 10.1016/j.aquaculture.2023.739303.
• Salvador-Mira M, Chico V, Arostica M, Guzmán F, Roher N, Perez L, ORTEGA-VILLAIZAN M. Immunomodulatory Lectin-like Peptides for Fish Erythrocytes-Targeting as Potential Antiviral Drug Delivery Platforms. Int. J. Mol. Sci. 2021. DOI: 10.3390/ijms222111821.

Patents and Available Technologies: 

1. Patent application (P202031141, OEPM, Spain)