Department: Biochemistry and Molecular Biology

Research Unit: Instituto de Neurociencias

Web page: 

http://www.umh.es/contenido/Estudiantes/:persona_147931/datos_es.html

http://in.umh-csic.es/personal-detalle.aspx?personal=421

Research Fields:

-Alzheimer´s disease, glycoslatyion, apoE, iPSCs

 Representative Publications:

• Escamilla S & Avilés-Granados C.. Cuchillo-Ibáñez I* “GluN2A-mediated currents and calcium signal in human iPSC-derived neurons” Scientific Reports 2026. *corresponding author. (Q1)
•  Marlies Gijs et al “A comprehensive scoping review of methodological approaches and clinical applications of tear fluid biomarkers”. Progress in Retinal and Eye Research 2025. (D1, IF: 18.7) Invited Review Article.
•  Escamilla S… Cuchillo-Ibáñez I*. “Synaptic and extrasynaptic distribution of NMDA receptors in the cortex of Alzheimer’s disease patients” Alzheimers Dement 2024. *corresponding author (D1. IF: 11.1).
•  Cuchillo-Ibañez I* et al. “The apolipoprotein receptor LRP3 compromises APP levels”. Alzheimers Res Ther. Nov 2021 *co-corresponding author (D1. IF: 8’835).
•  Cuchillo-Ibañez I et al. “Heteromers of amyloid precursor protein in cerebrospinal fluid”. Mol Neurodegener. 2015 (D1. IF: 6’51).
•  Cuchillo-Ibañez I* et al. “The β-amyloid peptide compromises Reelin signaling in Alzheimer’s disease”. Sci Rep. 2016 (Q1. IF: 4’259). *co-corresponding author.
•  Cuchillo-Ibañez I* et al “Reelin in Alzheimer’s disease, increased levels but impaired signaling: when more is less”. J Alzheimers Dis. 2016. (Q1. IF:  3.534). *co-corresponding author. Revisión.
•  Cuchillo-Ibanez I*, Seereeram A, Byers HL, Leung KY, Ward MA, Anderton BH, Hanger DP. “Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin”. FASEB J. 2008. *corresponding author (D1, IF: 7’049).
• Cuchillo-Ibáñez I & Rodríguez-Martín T, Noble W, Nyenya F, Anderton BH, Hanger DP. “Tau phosphorylation affects its axonal transport and degradation”. Neurobiol Aging. 2013. (D1. IF: 4’853).

Patents and Available Technologies:

1. “Patrón de glicosilación de sAPPα y/o sAPPβ como biomarcador diagnóstico de la enfermedad de Alzheimer, método y kit basados en el mismo”. P202030671. País de prioridad: España. Fecha de prioridad: 01/07/2020. Entidad titular: UMH/ CIBERNED / CSIC. Inventores: Sáez-Valero J., Lopez-Font I., Cuchillo-Ibañez I., Boix Rodriguez C.P.
2. “Method and diagnostic kit for Alzheimer’s disease based on detection of apolipoprotein E”. P202230224. Solicitud de patente europea nº 23769971.5. Extensión internacional en EEUU:  App. 18/887,336, 2025. Inventores: J Sáez-Valero, M Lennol, I Cuchillo-Ibáñez.