Department: Biochemistry and Molecular Biology

Research Unit: Instituto de Biotecnología y Salud (IDiBE)

Web page: 

http://www.umh.es/contenido/Estudiantes/:persona_136920/datos_es.html

https://ibmc.umh.es/mherranz.asp

Research Fields:

-Study of molecular, metabolic, and tumor microenvironment reprogramming induced by obesity in different types of cancer, with the aim of identifying therapeutic vulnerabilities and assessing their clinical relevance.

-Nutraceuticals and bioactive compounds with therapeutic potential in obesity.

-Development of in vitro skin models for the screening and functional validation of cosmetic ingredients.

Representative Publications:

• Jesica Martínez-Godfrey, Irene Pomares-Bri, Paula de Juan-Maciá, Mariló Olivares-Vicente, Enrique Barrajón-Catalán, Vicente Micol, Enrique Roche, María Herranz-López. Beyond Adipose Tissue Dysfunction: Innovations in Obesity Treatment. Obesity Reviews,
• Irene Pomares-Bri, Marta Roca, Fernando Borrás, Martin Wabitsch, Agustín Lahoz, Vicente Micol, María Herranz-López. Polyphenols reverse hyperglycemia-induced adipocyte dysfunction: A Metabolomic and Lipidomic study of efficacy. Food Research International, 2025. https://doi.org/10.1016/j.foodres.2025.116453.
• Patricia Fernández-Moreno, María del Carmen Villegas-Aguilar, María de la Luz Cádiz-Gurrea, María Herranz-López, Enrique Barrajón-Catalán, David Arráez-Román, Antonio Segura-Carretero, Álvaro Fernández-Ochoa. Untargeted metabolomic approach to assess the acute metabolism and urinary excretion of olive leaf bioactive compounds in humans. Food Research International, 2025. https://doi.org/10.1016/j.foodres.2025.117752.
• Herranz-López, M., Agustín, R. MS., Olivares-Vicente, M. et al.Patterns of circulating cytokines after 2 types of exercise in active type-1 diabetic patients. J Physiol Biochem, 2025. https://doi.org/10.1007/s13105-025-01123-5
• Olivares-Vicente, M.; Herranz-López, M. (CA). The Interplay Between Oxidative Stress and Lipid Composition in Obesity-Induced Inflammation: Antioxidants as Therapeutic Agents in Metabolic Diseases.  J. Mol. Sci.2025, https://doi.org/10.3390/ijms26178544.
• Mariló Olivares-Vicente, Noelia Sánchez-Marzo, María Herranz-López (CA), and Vicente Micol. Analysis of Lemon Verbena Polyphenol Metabolome and Its Correlation with Oxidative Stress under Glucotoxic Conditions in Adipocyte. Journal of Agricultural and Food Chemistry,2024. DOI: 10.1021/acs.jafc.3c06309.
• Boix-Castejón, E. Roche, M. Olivares-Vicente, F.J. Álvarez-Martínez, Herranz-López (CA), V. Micol, Plant compounds for obesity treatment through neuroendocrine regulation of hunger: A systematic review. Phytomedicine,2023. https://doi.org/10.1016/j.phymed.2023.154735.
• Marina Boix-Castejón, María Herranz-López (CA), Mariló Olivares-Vicente, Paula Campoy, Nuria Caturla, Jonathan Jones, Juan M. Zazo, Enrique Roche, Vicente Micol. Effect of metabolaid® on pre- and stage 1 hypertensive patients: A randomized controlled trial. Journal of Functional Foods, 2021. https://doi.org/10.1016/j.jff.2021.104583.
• María Herranz-López, Mariló Olivares-Vicente, Esther Rodríguez Gallego, Jose Antonio Encinar, Almudena Pérez-Sánchez, Verónica Ruiz-Torres, Jorge Joven, Enrique Roche, Vicente Micol, Quercetin metabolites from Hibiscus sabdariffa contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro. Food and Chemical Toxicology, https://doi.org/10.1016/j.fct.2020.111606.
• Boix-Castejón M., Herranz-López M. (CA), Pérez Gago A., Olivares-Vicente M., Caturla N., Roche E., Micol V. Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: A randomized controlled trial. Food and Function, 2018. DOI: 10.1039/c8fo00367j.

Patents and Available Technologies: 

1. Obtención y purificación de carotenoides a partir de subproductos de la industrialización del caqui. Mitra Sol. Technologies S.L. Nº de solicitud: ES20170000646 20170620. Fecha de registro: 20/12/2018.
2. Composición de extractos vegetales con flavonoides para paliar los múltiples efectos de la contaminación del aire sobre la piel. Monteloeder, S.L. Nº de solicitud: ES20180030426 20180430. Fecha de registro: 30/04/2018.
3. «Composition for controlling weight by modulating levels of peptides involved in fullness and/or appetite» Reference: 20170294/2026; P201731147. Company: Monteloeder/UMH. Filing Date: 25/09/2017; Priority date (granted): 25/10/18. US and International Patent. Clasification: US 2020/0268823 (PCT/ES2018/070600).

Company agreements: 

She has participated in many research projects and translational activities with different companies (Monteloeder, SL, Innovation Labo, SL and Invitrotecnia, SL).